From PISA
Motorway A12 in direction Rome-Grosseto, exit ROSIGNANO. 
Take HIGHWAY SS1 in direction of GROSSETO. 
Exit at SCARLINO and continue in direction of Castiglione della Pescaia. 

From FLORENCE motorway for Siena.
Take the HIGHWAY in direction of GROSSETO. 
Then follow the indications for Castiglione della Pescaia

From ROME
Motorway in direction of Civitavecchia.
At Civitavecchia the motorway ends and therefore take the highway SS 1 in direction of Grosseto/Livorno. 
Take the exit GROSSETO NORD and continue in direction of Castiglione della Pescaia.